Acetazolamide EP Impurity F(Triethylamine salt) CAS 80495-47-2(Free Acid)
| CAS No. | 80495-47-2(Free Acid) |
| Molecular Formula | C8H9N7O6S4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Acetazolamide EP Impurity F(Triethylamine salt) (CAS 80495-47-2(Free Acid), C8H9N7O6S4C6H15N) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Acetazolamide EP Impurity F(Triethylamine salt) (C8H9N7O6S4C6H15N) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9N7O6S4 C6H15N |
| Molecular Weight | 528.64 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 8 |
| Sulfur Atoms | 4 |
Related Acetazolamide Standards
- Acetazolamide-d3 (CAS 1189904-01-5)
- Acetazolamide EP Impurity D HCl (CAS 120208-98-2)
- Acetazolamide Sodium Salt (CAS 1424-27-7)
- Acetazolamide EP Impurity D (CAS 14949-00-9)
- Acetazolamide EP Impurity G (CAS 2349-67-9)
- Acetazolamide EP Impurity C (CAS 32873-56-6)
- Acetazolamide Impurity 10 (CAS 32873-57-7)
- Acetazolamide Impurity 8 (CAS 4454-63-1)
Recommended Standards
- Emedastine Impurity 43 (CAS CATO-C4X-226743)
- Dapagliflozin Impurity 70 (CAS CATO-C4X-113870)
- Topiramate EP Impurity B (CAS 876403-98-4)
- 2-Amino-4-(3-methylpiperidin-1-yl)butanamide (CAS 1310096-12-8)
- Anthracen-1-ol (CAS 71036-28-7)
- 2-Chloro-3,4-difluoropyridine (CAS 1227502-41-1)
- Tert-butyl 2-cyano-6,6-dimethyl-3-azabicyclo[3.1.0]Hexane-3-carboxylate (CAS 956004-44-7)
- 3-Difluoromethoxy-4-fluorothiophenol (CAS 1807181-78-7)
- 2,2,2-Trifluoro-N-[2-(2-iodo-5-methoxyphenyl)ethyl]acetamide (CAS 172617-55-9)
- Protein Kinase C? Peptide Substrate (CAS 120253-69-2)
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